Primary care · evaluated online

Chronic fatigue

Persistent fatigue (>6 weeks) deserves a systematic approach. A clinician can order appropriate labs and develop a plan.

Licensed clinicians · Available in all 50 states
Chronic fatigue
Common Rx
Depends on cause
Time to feel better
Varies
Contagious
Depends on cause
Telehealth fit
Yes — common

What is chronic fatigue?

Chronic fatigue is persistent exhaustion lasting weeks to months that isn't fully relieved by rest. It's a common reason people seek care.

Causes include thyroid disease, anemia, depression, sleep disorders, vitamin deficiencies, medications, autoimmune conditions, ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome). A systematic workup usually identifies treatable causes.

Do I have chronic fatigue? Common signs

If most of these describe what you're experiencing, telehealth may be a good next step:

Persistent fatigue not relieved by rest Difficulty concentrating ("brain fog") Sleep that doesn't refresh Low energy for normal activities Muscle aches Headaches Sometimes worse after exertion (post-exertional malaise) Affects work and relationships Lasts 6+ weeks
Here's how it actually works
01
Tell us what's going on5-minute online intake covers your symptoms, history, and any photos.
02
A clinician reviewsLicensed in your state. Reviews your case and asks anything needed.
03
Rx to your pharmacyIf treatment is appropriate, the prescription goes to the pharmacy you choose.

What causes it

Many: depression, anxiety, hypothyroidism, anemia (iron deficiency), vitamin D deficiency, sleep apnea, insomnia, mononucleosis or post-viral, ME/CFS, fibromyalgia, autoimmune diseases (lupus, RA), medications, alcohol, untreated chronic conditions.

Is it contagious?

Depends on underlying cause.

Iron deficiency drives a lot of unexplained fatigue — especially in menstruating women — and ferritin is often normal-looking but low for symptom relief.

Can it be treated online?

Chronic fatigue evaluation is well-suited to telehealth. Severe progressive fatigue with weight loss, unexplained fevers, neurologic symptoms — need in-person workup. ME/CFS specifically benefits from specialty evaluation.

How chronic fatigue is treated

Treat identified causes. Iron deficiency: iron supplementation, target ferritin >75. Hypothyroidism: levothyroxine. Vitamin D: supplementation. Sleep apnea: CPAP. Depression: SSRIs, therapy. Insomnia: CBT-I and treatment. ME/CFS: pacing, supportive care; no specific cure but management strategies help.

Self-care while you wait

When to skip telehealth and seek emergency care Sudden severe fatigue with chest pain, shortness of breath, fainting — emergency. Unintentional weight loss with fatigue and night sweats — needs workup.

How long does it last?

With treatable causes addressed, weeks to months. Chronic conditions need ongoing management.

Frequently asked questions

What labs should I get?

Standard workup: CBC, ferritin, TSH, vitamin D, B12, basic metabolic panel. Targeted additional testing based on history.

Is it adrenal fatigue?

'Adrenal fatigue' isn't a recognized medical diagnosis. Adrenal insufficiency (Addison's) is a real but uncommon condition with specific lab findings.

How do I know if it's depression?

Depression often has low mood, loss of interest, sleep changes. Fatigue alone without these is less likely depression. Often coexists.

What is ME/CFS?

Distinct condition with profound fatigue plus post-exertional malaise, sleep issues, cognitive problems. Diagnosed by clinical criteria. No specific test.

Will exercise help or hurt?

For most fatigue, gentle gradual exercise helps. For ME/CFS, overexertion can severely worsen — pacing is key.

This page is for general information only — not a substitute for individual medical advice. A licensed clinician reviews every intake submitted through PrescriberNow before any prescription is issued. If you're experiencing a medical emergency, call 911 or go to the nearest emergency room.

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